PLOS ONE
Top medRxiv preprints most likely to be published in this journal, ranked by match strength.
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Abstract Background: Urinary tract infections (UTIs) are common health issue during pregnancy, often lead to adverse maternal and neonatal outcomes if left untreated, low knowledge contribute to high UTI rates, particularly in resource-limited settings like Jordan. To assess the knowledge levels about UTIs among pregnant women in Jordan and its association with socio-demographic characteristics. Methods: A descriptive cross-sectional study was conducted among 500 pregnant women attending anten...
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This systematic review and meta-analysis aimed to evaluate the effectiveness of relaxation interventions on anxiety, depression, stress, and quality of life in women with infertility. A comprehensive search of PubMed, OVID MEDLINE, CINAHL(R), Google Scholar, and Korean databases was conducted for articles published through March 2025. Keywords included combinations of terms related to infertility, ART, and nursing or psychotherapeutic interventions. The search identified 759 records, of which 13...
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IntroductionTraditional bone-setting remains a culturally significant healthcare practice in low- and middle-income countries, particularly in regions like Sudan where modern orthopedic services are often inaccessible or unaffordable .This study examines the role of traditional healing practices in orthopedic care in White Nile State, Sudan, assessing patient perceptions, treatment effectiveness, and sociocultural factors influencing healthcare choices. MethodsA cross-sectional analytical study...
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BackgroundRisk screening for pre-eclampsia relies on accurate gestational age assessment, but routine access to ultrasound-based gestational dating remains challenging in many low- and middle-income countries (LMICs). As part of the formative work for the "Preventing pre-eclampsia: Evaluating AspiRin Low-dose regimens following risk Screening" (PEARLS) trial, we aim to validate and implement an Artificial Intelligence (AI)-based algorithm for estimation of gestational age, using blind sweeps don...
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This study explores the influence of social determinants of health (SDOH) on follow-up behavior among patients referred to community-based organizations (CBOs) in the Emergency Department (ED) of Long Island Jewish (LIJ) Medical Center. A retrospective analysis was conducted on data collected from 342 patients who were screened for SDOH between February and July 2023. Descriptive statistics and Chi-squared tests were used to identify potential associations between demographic and social factors ...
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Background: Cesarean section is one of the most commonly performed surgical procedures worldwide and is frequently associated with moderate to severe postoperative pain. While overall pain after cesarean delivery is well described, evidence comparing pain intensity and analgesic use between primary and repeat cesarean sections remains limited. Objective: To compare postoperative pain severity and total analgesic consumption within the first 24 hours among women undergoing primary versus repeat c...
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BackgroundUndernutrition during pregnancy is a major public health issue and may lead to negative pregnancy outcomes. The body mass index (BMI), considered widely used as the reference method for assessing nutritional status due to its established population-based cut-off points; however, it can be misleading in pregnancy. This study aimed to validate the mid-upper arm circumference (MUAC) as a screening tool for identifying undernourished pregnant women (PW) in an urban slum, compared to BMI. ...
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IntroductionThe Southeastern region of Nigeria faces a severe public health challenge from hypertension due to its high prevalence. Psychological factors such as stress, anxiety, depression, coping mechanisms, and social support play essential roles in hypertension development and treatment, yet there has been limited scholarly attention to these factors in Nigerian and international qualitative research. This study addresses this evidence gap by investigating the psychological factors that infl...
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BackgroundGlaucoma is identified as one of the leading causes of blindness worldwide. Its chronic nature and the potential for irreversible vision loss contribute to significant distress among affected individuals. Around 25% of individuals with glaucoma are estimated to experience depression, negatively impacting their quality of life and treatment adherence. However, data on the prevalence of depression among people with glaucoma in Tanzania is limited. This study aimed to determine the preval...
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Introduction Glomerular filtration rate (GFR) is invasive to measure. Therefore, in clinical care, estimated GFR is derived from serum levels of endogenous filtration markers such as creatinine and cystatin C. Multiple studies from high income countries showed differences between estimated glomerular filtration rate based on cystatin C (eGFRcys) and creatinine (eGFRcr). This study aimed to assess the agreement between eGFRcys and eGFRcr in Ethiopian children and identify factors influencing high...
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BackgroundEvidence supports the key role research mentors play in bolstering the success of early stage investigators (ESI). However, there are limited data about the impact of supplemental, cross-disciplinary career mentorship and professional development opportunities for ESIs seldom included during academic training. We assessed the perceived value of this approach among post-doctoral fellows and early career faculty who participated in a multi-component career mentoring program organized by ...
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BackgroundPreterm premature rupture of membranes (PPROM) is a leading contributor of adverse perinatal outcomes, particularly in low-resource and conflict-affected settings. Despite its clinical importance, prospective evidence on its impact on composite adverse perinatal outcomes in northern Ethiopia remains limited. This study examined the impact of Preterm premature rupture of membranes on composite adverse perinatal outcomes and identified associated predictors among pregnant women in public...
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BackgroundIndustrial and peri-urban settings present complex health challenges driven by occupational exposures, environmental risks, and socioeconomic vulnerability. Despite ongoing health education and preventive efforts, many populations living and working in such settings continue to experience significant unmet health needs that limit wellbeing and access to care. MethodsThis cross-sectional qualitative study was conducted in Namanve Industrial Park and surrounding communities in Mukono Di...
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BackgroundCompetence-Based Education (CBE) in physiotherapy aims to equip graduates with essential capabilities for safe and effective practice. Frameworks often include domains like clinical reasoning, communication, and professionalism. Despite its alignment with healthcare needs, CBE implementation in higher education remains inconsistent. Many educators still rely on behaviourist paradigms focused on passive learning and binary assessments, which inadequately reflect professional competence....
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IntroductionWe aim to examine whether state-level telehealth policies in 2020 were associated with a reduction in the urban-rural disparity in telehealth utilization. MethodA multilevel model was used to assess state actions impact on urban-rural differences in healthcare utilization. We used the percentage of Medicare Fee-for-Service beneficiaries receiving any telehealth services (measured by county level) in 2020 as the dependent variable. We examined the following state-level policies as ke...
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The recent Lancet Commission on Nigerias health system highlighted high out of pocket expenditures on health and underfunding of the public health sector as major obstacles to Nigerias achievement of the Sustainable Development Goals. Nigeria has sought to address these gaps by extending health insurance coverage. This paper measures health insurance coverage and access to care in Nigeria circa 2023, using the first round of the Peoples Voice Survey (PVS). We analyze health insurance coverage by...
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PurposeRobotic walkers are a new and novel technology with growing evidence of benefits for children living with mobility impairments. However, little is known about how using these devices at home impacts families. This study aims to explore parents perceptions of home-based robotic walking and the impacts on their family and their child living with a mobility impairment. Materials and MethodsQualitative interviews were conducted with seven parents who have a child who used a robotic walker in...
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BackgroundVision loss represents a significant public health concern according to the World Health Organisation, with increasing global age-standardised prevalence rates. Visual impairments are disproportionately distributed, occurring eight times more frequently in Sub-Saharan Africa and Southeast Asia compared to high-income regions. The Interprofessional Education (IPE) approach, utilizing the Arclight package as an implementation vehicle, offers promising potential for collaborative early de...
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BackgroundIn 2004, South Africas public health system faced the dual challenge of rapidly scaling up antiretroviral therapy (ART) while reducing the cost of laboratory monitoring. At the time, conventional CD4 testing methods were expensive, labour-intensive, and impractical for sustaining a national testing network. This study aimed to assess the financial impact and cost savings associated with the implementation of the PanLeucogated CD4 (PLG/CD4) enumeration method between 2004 and 2024 in th...
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Burnout, a state of chronic exhaustion often characterized by feelings of emotional exhaustion, cognitive and emotional dysregulation, and psychological distancing, is an increasingly recognized issue within most professions. This syndrome results in diminished job satisfaction, strained interpersonal relationships, and decreased well-being. Socio-demographic factors have been shown to play a role in burnout risk, while trait mindfulness has been identified as an effective method to mitigate it....